What You Need to Know
These peptides are ribosomally synthesized and undergo post‑translational modifications such as dehydration and cyclization, conferring resistance to proteases and heat. Their mode of action involves pore formation in target cell membranes, leading to ion leakage and cell death. The activity is highly dependent on temperature, pH, and ionic strength, which influence peptide folding and stability.
The Science
Primary Reaction
Ribosomal synthesis and post‑translational modification of antimicrobial peptides (bacteriocins) by lactic acid bacteria